The Power of Pharmacokinetics

MERREM I.V. penetrates well into most body fluids and tissues 1

  • Penetrates well into cerebrospinal fluid, achieving concentrations matching or exceeding the minimum inhibitory concentrations (MICs) for most susceptible bacteria 1
  • After a single intravenous dose of MERREM I.V., the highest mean concentrations of meropenem were found in fluids and tissues at 1 hour (0.5 to 1.5 hours) after the start of infusion except where indicated in the Prescribing Information 1 (see table 1 in MERREM I.V. Prescribing Information)
  • The pharmacokinetics of meropenem in pediatric patients 2 years of age or older are essentially similar to those in adults 1
Chart: Plasma meropenem concentration profil and MIC90 for susceptible pathogens

* Pseudomonas aeruginosa
† Bacteroides fragilis
‡ Streptococcus pneumoniae
§ Staphylococcus aureus (MSSA only)
// Escherichia coli
Klebsiella pneumoniae
# Neisseria meningitides

Prescribing Iformation